Introduction to the network

Welcome to the EU network Rationalising Membrane Protein crystallisation “RAMP”. This is an Innovative Training Network (ITN) funded by the EU under the programme Marie Skłodowska Curie Action, grant 722687.

Crystallising membrane proteins is very hard – proteins are big complex flexible molecules, and to make life even harder membrane proteins live in a soft back-to-back double layer of soap-like molecules. But we need crystals of membrane proteins to use X-ray diffraction to determine the protein’s detailed structure, and we need this structure to design drugs to target membrane proteins.

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Crystals of a membrane protein grown by Heidi Burke now of Sanofi Genzyme, but then Tufts Sackler School of Biomedical Sciences

So crystallising membrane proteins is both a very difficult problem and an important problem. If we knew the structure of more membrane proteins we would know about how our bodies work at a molecular level, and be better able to develop life saving drugs.

The network aims to develop new approaches to crystallising membrane proteins, approaches that rely on less trial and error than current approaches. It will also crystallise membrane proteins that have never been crystallised before, and train 12 PhD students to do all this. The 12 students will learn the research and team working skills, and the commercial awareness, needed for a successful research career.

The EU in the 21st century needs the scientists we will train, and the new techniques we will develop. They will both benefit society with more effective, safer, drugs, and make the EU’s high tech economy more competitive.

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News

April 2021, new publication from Sofia Jaho (ESR 2) et al.: Crystallization of proteins on chip by microdialysis for in situ X-ray diffraction studies in Journal of Visualized Experiments @JoVEJournal

1st of April 2021, Jannik Straus (ESR 4) gave a talk at BCA and BACG Joint Online Meeting 2021 for the BSG membrane protein session (N°3)!

March 2021, new publication from Elham Vahdatahar (ESR 1) et al.: Optimization of Crystal Growth for Neutron Macromolecular Crystallography in Journal of Visualized Experiments @JoVEJournal